Human PK Prediction Intern Overview

Envision spending your summer working with energetic colleagues and inspirational leaders, all while gaining world-class experience in one of the most dynamic organizations in the pharmaceutical industry. This is a reality for AbbVie Interns.

The Translational Pharmacokinetics and DDI Sciences group within the Quantitative , Translational & ADME Sciences (QTAS) department at AbbVie is seeking an intern to join the team for 1 0- 12 weeks . This group’s main function is to utilize in vitro and in vivo preclinical data to predict human PK and DDI parameters of investigational small molecules and provide dose /DDI projections to facilitate their successful transition into first-in-human studies . The intern will execute various prediction methods including, but not limited to, allometric scaling , in vitro-in vivo extrapolation (IVIVE) , and mathematical modeling , and conduct a comprehensive evaluation of predictive performance using both internal and external data . This work will contribute to the team’s strategies in employing these techniques and enabling rational decision-making to support the development of new potential drug candidates.

Key responsibilities include:

• Conduct a comprehensive literature review to gather and synthesize relevant information regarding human PK and DDI prediction methods
• Perform mathematical prediction s of human PK /DDI parameters in compounds from both external data and AbbVie's internal databas e
• Evaluate predictive performance against clinically observed data
• Analyze and interpret data and present findings to the QTAS department and other relevant stakeholders

Min imum Qualifications

• Currently enrolled in university, p ursuing a Master’s or PhD in Pharmaceutical Science, Pharmacology, Biology, Biochemistry, Chemical/Biochemical Engineering, or other related field
• Must be enrolled in university during the internship period
• Expected graduation date between August 2024 and June 2025
• Exposure to basic ADME principles and in vivo pharmacokinetics (e.g. clearance, F%) concepts
• Proficiency with MS Office Suite

Preferred Qualifications

• Experiences with modeling software ( e.g. Phoenix WinNonlin, Simcyp, Gastroplus )
• Experience with PK modeling
• Strong analytical and problem-solving skills
• Excellent attention to detail and ability to work independently
• Enthusiasm and willingness to learn

Benefits and Amenities

• Competitive pay
• Relocation support for eligible students
• Break rooms stocked with complimentary coffee, tea, cold beverages, healthy snacks, and cold breakfast items
• Onsite café and fitness center

Equal Employment Opportunity

At AbbVie, we value bringing together individuals from diverse backgrounds to develop new and innovative solutions for patients. As an equal opportunity employer we do not discriminate on the basis of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information gender identity or expression, sexual orientation, marital status, protected veteran status, or any other legally protected characteristic.

About AbbVie

AbbVie’s mission is to discover and deliver innovative medicines that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people’s lives across several key therapeutic areas: immunology, oncology, neuroscience, eye care, virology, women’s health, and gastroenterology, in addition to products and services across its Allergan Aesthetics portfolio.

For more information about AbbVie, please visit us at www.abbvie.com .

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AbbVie’s mission is to discover and deliver innovative medicines that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people’s lives across several key therapeutic areas: immunology, oncology, neuroscience, eye care, virology, women’s health and gastroenterology, in addition to products and services across its Allergan Aesthetics portfolio.